Episode Details

In this in-depth episode of The Histamine Well Podcast, Joanne explores why hormone symptoms often persist despite treatment, and what may be driving this beneath the surface.

Drawing on clinical observation and biochemistry, Joanne explains how chronic inflammation, histamine dysregulation, and methylation imbalances interact to disrupt hormonal signaling, ovulation, and recovery.

If you’ve tried supplements, improved your diet, and still experience symptoms like PMS, PMDD, anxiety, insomnia, migraines, or hormonal acne, this episode provides a deeper framework for understanding why.

What You’ll Learn

• Why hormones may not improve despite treatment
• How inflammation disrupts ovulation and lowers progesterone
• The connection between histamine intolerance and estrogen dominance
• Why symptoms worsen around ovulation and before your period
• The role of methylation in estrogen detoxification
• Differences between overmethylation and undermethylation
• Why some supplements may worsen symptoms
• Key drivers behind PMS, anxiety, sleep issues, and hormonal imbalance

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