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Beyond RCTs: Real-World Evidence and the Future of Sleep Research (w/Dr. Ellen Stothard) [Ep.147]

Beyond RCTs: Real-World Evidence and the Future of Sleep Research (w/Dr. Ellen Stothard) [Ep.147]

Episode 147 Published 2 months, 1 week ago
Description

Episode Summary

In this in-depth conversation, I welcome Dr. Ellen Stothard, PhD, a sleep researcher with expertise in integrative physiology, neuroscience, and data analytics. Ellen shares her unconventional journey from psychology student to sleep science researcher to clinical data specialist, offering a unique perspective on what "evidence-based" really means and how clinicians can become everyday researchers.

 

Key Topics Covered

Ellen's Journey

  • From psychology and French double major to a PhD in sleep and circadian rhythms
  • The famous "Camping Study" and how natural light synchronizes our bodies
  • Why academia wasn't the right fit and finding purpose in clinical data
  • Building Rebus Health: an integrative sleep medicine clinic

Understanding Evidence-Based Practice

  • What "evidence-based" actually means (and what it doesn't)
  • The difference between correlation and causation
  • Why negative findings are crucial but rarely published
  • Real-world evidence vs. randomized controlled trials

Research Methodology Demystified

  • Small, controlled studies (N=30) vs. large observational studies (N=50,000)
  • Understanding statistical significance and what research can (and can't) tell you
  • The importance of understanding study assumptions and limitations
  • Why averages hide responders and non-responders

Clinical Practice as Research

  • How busy practitioners can gather research-quality data
  • The power of before-and-after documentation
  • Why consistency matters more than perfection
  • Overcoming IRB fears: private IRBs and retrospective chart reviews

Early Intervention vs. Watchful Waiting

  • The ethics of withholding treatment when harm is suspected
  • Using "natural experiments" from patients who delayed treatment
  • Why inaction carries responsibility too

Breaking Down Silos

  • Why dentists, sleep physicians, and researchers need to collaborate
  • The psychology of professional resistance to change
  • Creating bridges between academia and private practice
  • Speaking each other's "language" across disciplines

Memorable Quotes

-"The absence of evidence is not the evidence of absence."

-"You can only call it evidence-based if you know what the science says AND what it doesn't say."

-"If you're not looking, you won't necessarily find it."

-"We can't just say 'okay, you feel better, bye.' We need to understand: you came in, you tested this way, we did something, it made you better. What happened?"

-"Your clinical data IS evidence. You have the ability to generate the evidence yourselves."

Practical Takeaways for Clinicians

  • Start gathering before-and-after data consistently
  • Use validated questionnaires when possible (or create standardized questions)
  • Document outcomes at regular intervals
  • Consider hiring data analysts or partnering with graduate students 
  • Explore private IRBs for faster, easier research approval 
  • Retrospective chart reviews can be powerful research tools 
  • Looking at your outcomes makes you a better clinician

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