Episode Details

In this episode of The Histamine Well Podcast, Joanne explains how Helicobacter pylori (H. pylori) can quietly drive histamine intolerance, SIBO, and hormone imbalance — even without classic ulcer or reflux symptoms.

H. pylori produces urease, converting urea into ammonia and lowering stomach acid. This reduction in hydrochloric acid can impair protein digestion, weaken pathogen control, and disrupt digestive signaling — creating the perfect environment for small intestinal bacterial overgrowth (SIBO) and rising histamine levels. The result can be a “histamine storm” of inflammation and systemic symptoms.

Common signs may include:

• Food reactions
• Bloating and gas
• Hives or eczema
• Anxiety and insomnia
• Headaches
• PMS, estrogen dominance, and perimenopause flares

Joanne also discusses the pros and cons of triple therapy (antibiotics plus proton pump inhibitors), post-treatment gut repair, and natural strategies such as sulforaphane and gut-healing support.

If your histamine symptoms persist despite dietary changes, this episode explores a deeper gut–histamine–hormone connection that may be driving the root cause.

What You’ll Learn:

• How H. pylori disrupts stomach acid and digestion
• The link between low stomach acid, SIBO, and histamine intolerance
• Why mast cell activation increases systemic symptoms
• How histamine impacts estrogen and perimenopause
• Treatment considerations and natural support options

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