Episode Details

Psychiatric Services Branch, Department of Public Health, and Department of Psychiatry, University of Saskatchewan, Saskatoon, SaskatchewanI. Introduction .II. Biochemistry of AdrenochromeIII. Action of Adrenochrome on CellsIV. Effect of Adrenochrome on FishV. Effect of Adrenochrome on SpidersVI. Effect of Adrenochrome on PigeonsVII. Effect of Adrenochrome on MammalsA. Mice .B. Rats .C. RabbitsD. Cats .E. Dogs .F. MonkeysVIII. Effect of Adrenochrome on ElectrogramsIX. Effect of Adrenochrome and Adrenolutin on HumansA. Adrenolutin Double Blind ExperimentsB. Prolonged Reactions to Adrenochrome and AdrenolutinC. Effect of Adrenochrome on Humans as Reported by other Laboratories D. Adrenochrome Given SublinguallyE. Potentiation of the Action of AdrenochromeF. DiscussionX. Mode of Action of AdrenochromeXI. ConclusionsReferencesDISCUSSIONThe basic issue is whether or not adrenochrome and compoundswhich can be derived from it in vivo, perhaps adrenolutin and 5,6-dihydroxy-N-methylindole, are active hallucinogens in man. Theevidence that these compounds exist in the body is growing moresubstantial. The fact that these compounds are active in producingchanges in animals can no longer be denied, and indeed it was concludedby Kety ( 1959) that there was no doubt it did producechanges in animals. Adrenochrome will therefore be most interestingto physiologists who are following the properties of metabolicproducts of epinephrine.The fact that adrenochrome and adrenolutin have producedchanges in the perception, thinking, and feeling of humans makesthem very interesting for psychiatrists and physiological psychologists.Although Smythies ( 1960) denies that adrenochrome is activein humans, the literature reviewed in this paper, as well as thedetailed outline of new data from our research, makes clear that itis no longer sufficient merely to state that adrenochrome is notactive.Adrenochrome and adrenolutin are chemically very reactive substancesand react with an amazing variety of constituents of thebody. They could therefore somehow interfere with sensory perception.However, the evidence gathered in this review suggests clearlythat the brain is the chief target. This evidence is that ( 1) giveninto the ventricles of the brain, the compounds are much moreactive than when given by vein; ( 2) pretreatment with taraxein,LSD, and ALD potentiates their action; ( 3) pretreatment withceruloplasmin protects the animal against their toxic effect; ( 4)adrenochrome produces hypothermia in normal and adrenalectomizedrats (Hutcheon et al., 1956) without decreasing the consumptionof oxygen ( Eade, 1954); and ( 5) anxiety increases the susceptibilityof normal human subjects to adrenolutin (Hoffer, 1957 c).Thanks for stopping by. We bring rare and forgotten audio books to the world. Books on Theosophy, Spiritualism, History, Political Philosophy, Forteana, Secret Societies, Magic, Occultism, Mystery Schools, Mythology, Ancient Wisdom, Religion. We'll be highlighting on this channel some very interesting audiobooks. Sometimes it can only be a sample, but when possible we will share the whole book. And hopefully we can find some other creative ways on this channel to bring you some interesting audiobook content. You can find all of our books at adult brain . ca and for the full versions you can go straight to Audible or Itunes/Apple Books.