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PSYCHEDELIC COMPOUNDS

That No One Has Made But I Think I Would Love

Episode Six: THALASSINE-7

(7-OH-Mitragynine-DMT Conjugate / Sigma-2 Agonist / Cortistatin Analog)

“The compound that puts you in the water. The water that is already in you.”

✦

Episode Summary

This episode delivers a haunting, second-person narrative of THALASSINE-7, a purely theoretical psychedelic that doesn’t flood you with new visions — it turns up the volume on what your body is already screaming, clears the static of self-protection, and holds you in crystal-clear confrontation with the self at depth.

Framed through a father and his nine-year-old daughter’s real-time fight against a rip current at Three Tables Beach on Oahu’s North Shore, the “trip” becomes an unflinching mirror for overconfidence, the weight of trust, ignoring warning signs, and the difference between survival and wisdom.

The Compound (Theoretical Pharmacology)

•  Backbone: Modified 7-hydroxymitragynine redirected from opioid receptors to sigma-2 agonism (mitochondrial receptors that govern the cellular “continue or quit” decision — literally apoptosis/survival signaling).

•  Psychedelic Link: 5-substituted DMT moiety connected via sulfonyl linker, creating allosteric cross-talk that amplifies whatever signal your nervous system is already broadcasting instead of overlaying new hallucinations.

•  Rest Component: Cortistatin-14 analog — the same neuropeptide your brain releases in deep slow-wave sleep — brought into full waking consciousness to quiet hippocampal chatter and deliver profound, low-static rest while you remain completely alert.

Net Effect: Complete wakefulness + total removal of narrative armor + inescapable bodily truth = an encounter with reality you cannot file away.

Status: 100% theoretical / fever-dream medicinal chemistry. No one has synthesized this. The lessons it forces are very real.

The Trip Report: Three Tables Beach, Pupukea, North Shore Oahu

Setting: Overcast grey morning at the beach named for three flat coral reef tables visible at low tide. Multiple posted signs warn of powerful rip currents, hazardous shorebreak, and past deaths. The father enters the water anyway with his trusting daughter on his back.

Key Moments (clinical timestamps from the narrative):

•  T+0:00 — Reading the signs… and walking in.

•  T+0:22 — The current slams. Sigma-2 receptors light up with the body’s primal “continue” verdict.

•  T+0:25–0:41 — Arm-over-arm fight; daughter silent, gripping, sixty-two pounds feeling like the entire world.

•  T+0:58 — Shore reached. Arms shaking in six inches of water. Pride and reckoning land simultaneously.

•  T+1:20 — The compound forces both truths at once: I brought her back and I never should have taken her in.

•  T+2:00 — Integration on the sand: You are not the exception. Do the work in calm water before the current changes again.

Real Location Note

Three Tables Beach (also called Kalua o Māua) is a real spot between Waimea Bay an