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Back on your GLP-1 medication… but confused why it isn’t working this time?

Lots of people stop these medications for valid reasons. Cost, side effects, pregnancy plans, or simply because things were going well and it felt like the right time to try managing without them. But when weight creeps back on and you restart, it can feel really frustrating when results don’t look the same.

In this episode, I talk through why that happens. Factors like muscle loss, metabolism changes, weight regain patterns, and higher stress levels can all change how your body responds the second time around. If you’re feeling stuck or wondering what changed, this episode will help you make sense of what’s going on and figure out your next steps without beating yourself up.

References

Get the free podcast roadmap for The Obesity Guide

Jane Pilger: The Gathering

A monthly guided experience to help you slow down and learn how to trust yourself.

Slowing Down to the Speed of Joy by Matthew Kelly 

Back to Basics Mini Podcast Series 2025

Ep. 100: Hydration

Ep. 101: Protein

Ep. 102: Fiber

Audio Stamps

00:30 - Why GLP-1 medications may stop working when you restart them after taking a break.

01:20 - Book recommendation: "Slowing Down to the Speed of Joy" and how constant busyness prevents you from addressing behaviors that aren't serving you.

04:04 - The common pattern: success, stopping medication, weight regain, then struggling when restarting.

06:25 - Why it's harder the second time: muscle loss, weight cycling, and mismanaged expectations all impact your results.

09:00 - The importance of updated lab work and comprehensive metabolic assessment before restarting.

10:35 - How chronic stress and high cortisol prevent weight loss, even on medication.

14:35 - The real work: learning nervous system regulation instead of constantly fighting cravings and urges.

All of the information on this podcast is for general informational purposes only. Please talk to your physician and medical team about what is right for you. No medical advice is being on this podcast.

If you live in Indiana or Illinois and want to work with doctor Matthea Rentea, you can find out more on www.RenteaClinic.com

Not Sure Where to Start With the Podcast? I’ve Got You.

Get my free Podcast Roadmap—a simple guide to help you find the episodes that matter most to your journey. Whether you're on GLP-1s, navigating plateaus, or just starting out, there's something here for you.

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