Episode Details

00:00 Intro & Schizophrenia Research Overview

00:11 Genetic and Environmental Foundations

00:31 Neurotransmitters and the Dopamine Hypothesis

01:56 Role of Stress and Trauma

03:32 Neurological Findings in Schizophrenia

06:59 Autoimmune Disorders and Inflammation

10:04 Inflammation & Immune System Impact

13:06 Stress Hypothesis and PTSD Link

15:44 Childhood Trauma and Brain Development

17:01 Physical Stress & Sleep Deprivation

17:59 HPA Axis, Cortisol, and Neurotoxicity

20:31 Hormonal Influences: Estrogen, Testosterone, Oxytocin

27:00 Testosterone Effects in Men & Women

31:02 PCOS, Testosterone & Psychosis Risk

34:39 Oxytocin's Role in Stress and Social Function

35:46 Gut Microbiome and Schizophrenia

38:42 Microbiome Imbalances and Supplementation

41:06 Diet, Blood Markers & Monitoring Insights

43:13 Wearable Tech & Digital Biomarkers

44:08 Medication Impacts & Side Effects

45:53 Sleep Disruption and Psychotic Symptoms

47:07 Deep Sleep, Memory & Inflammation

50:53 Sleep Architecture in Schizophrenia

53:01 Antipsychotics, Fatigue, and Motivation

54:25 Vagus Nerve & Parasympathetic System

55:28 Neuromodulation: Ultrasound & Alternatives

56:34 Key Takeaways: Stress, Inflammation, and Recovery

58:00 Q&A: Oxytocin Nasal Spray & New Therapies

59:09 Empowerment and Reducing Relapses

01:00:31 Menopause, Estrogen & Late-Onset Schizophrenia

01:01:31 GABA, Glutamate, and Brain Chemistry Recap

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