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#233 The Science of Hunger: GLP-1, Appetite Control & Natural Weight Management With Sarah Kennedy
Description
Why does hunger feel so loud — and why does willpower so often fail?
In this illuminating episode, Sarah Kennedy, founder and CEO of Calocurb, unpacks the biology of hunger, the gut-brain axis, and the powerful role of GLP-1 in appetite regulation. Drawing on over 15 years and $30 million of New Zealand government-backed science, Sarah explains why hunger is driven by our most primitive brain systems — and how understanding this biology can finally bring peace with food.
We explore how bitter taste receptors in the gut stimulate appetite-suppressing hormones, why dieting can actually increase hunger over time, and how natural GLP-1 activation differs fundamentally from pharmaceutical injections like Ozempic.
We explore:
- The evolutionary biology of hunger and food noise
- How GLP-1, CCK and PYY regulate appetite
- Why calorie restriction backfires long-term
- Natural vs synthetic GLP-1 pathways
- How appetite regulation supports metabolic health, insulin sensitivity & longevity
This is a science-grounded, compassionate conversation that reframes hunger — not as a personal failure, but as biology you can finally work with.
This episode was brought to you by:
- Calocurb