Episode Details

In this episode we break down skin substitutes for diabetic foot ulcers: how they work biologically, why they are not interchangeable, and common errors clinicians make.

We review major categories and examples (bioengineered cellular grafts like Apligraf and Dermagraft; human dermal matrices like AlloDerm and GraftJacket; placental/amniotic products like EpiFix and Grafix; xenografts such as Integra; and synthetic matrices like OASIS), plus inclusion/exclusion criteria.

Practical application rules are emphasized: sharp debridement to bleeding tissue, infection control, optimized perfusion, strict offloading, proper dressing, and documentation. Stop after 2–3 failed applications and remember grafts are tools—not cures.