Episode Details

This episode examines King George III's documented episodes of severe mental illness and modern re-evaluation (bipolar disorder vs porphyria), then connects the biology of stress—HPA axis, cortisol, and catecholamines—to impaired diabetic foot ulcer healing.

It explains how depression, agitation, and self-neglect worsen outcomes and outlines a humane, multidisciplinary modern treatment plan that pairs wound care with psychiatric and geriatric support to improve limb salvage.