Episode Details
Back to EpisodesHow to stall a copy machine
Description
TWiV explains how remdesivir inhibits the SARS-CoV-2 RNA polymerase: the drug is incorporated into the growing RNA chain and causes synthesis to stall when the drug clashes with an amino acid in the active site.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode
- How remdesivir stalls the SARS-CoV-2 polymerase (Nat Comm)
- Movie of polymerase stalling (Nat Comm)
- Second mechanism of remdesivir inhibition (J Biol Chem)
- Watson Crick molecular model (Science Museum Group)
- Letters read on TWiV 819
- Timestamps by Jolene. Thanks!
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Intro music is by Ronald Jenkees
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