Episode Details

This episode covers: 

• Nano CBD Pain Relief Without Cognitive Side Effects 

A new nano-micelle formulation of CBD called CBD-IN delivers fast, non-addictive pain relief in mice without memory issues, motor impairment or the usual cannabinoid “fog.” Because it crosses the blood brain barrier and directly targets hyperactive pain circuits, it sidesteps many opioid-type drawbacks. Dave explains why precision-designed cannabinoids could reshape chronic pain treatment and longevity support. 

Source: https://www.sciencedaily.com/releases/2025/11/251117095652.htm    

• Moderate Calorie Restriction Slows Biological Aging 

A long-term trial from the National Institute on Aging found that cutting calories by about 12% over two years slowed the pace of aging — measured by methylation clocks and metabolic markers — in lean and mildly overweight adults alike. Dave breaks down why small, manageable dietary tweaks can deliver big longevity gains, without crash dieting or extreme fasting. 

Source: https://www.nia.nih.gov/news/cutting-calories-may-slow-pace-aging-healthy-adults   

• FDA Approves AI-Guided Robotic Surgery Trials for Alzheimer’s 

The U.S. Food and Drug Administration (FDA) has granted IDE approval for the first robotic microsurgical study targeting early stage Alzheimer’s disease using AI and deep imaging. The trial uses adaptive robotics to target deep brain lymphatic pathways, potentially clearing amyloid/tau deposits with surgical precision. Dave explains why this signals a new era in neurodegeneration – moving from drug-only to machine-assisted brain repair. 

Source: https://www.mmimicro.com/ide-approval-for-first-robotic-microsurgery-alzheimers-study/   

• Antibiotic Reprograms Gut Bacteria to Produce Anti-Aging Molecules 

Researchers demonstrated that the veterinary antibiotic cephaloridine can reprogram gut microbes to secrete colanic acid — a molecule linked to better mitochondrial health, reduced gut permeability and improved cholesterol/insulin balance in mice. Dave explores how this could evolve into a pipeline of engineered probiotics that act as internal “longevity factories.” 

Source: https://newatlas.com/aging/antibiotic-longevity-microbiome/ (link remains unchanged) 

• Klotho: The Longevity Protein Nears Clinical Reality 

The longevity protein Klotho, known for clearing toxic by-products, calming inflammation and protecting brain/organ networks, is now advancing toward human trials via injectables, oral formats and gene therapy. Dave explains why Klotho is shaping up as a foundational target for next-gen age-reversal strategies and stacking protocols. 

Source: https://investingnews.com/longevity-focused-health-fueling-u-s-anti-aging-products-market-projected-to-reach-27-billion-by-2033/ (link remains unchanged) 

All source links provided for easy reference to the original reporting and research above. 

This episode is essential listening for fans of biohacking