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We'll Pay $101 Million If You Prove You Can Reverse Aging
Subscribe to our channel: / @optispan Get Our Newsletter (It's Free): https://www.optispan.life/Join me for a fascinating conversation with Dr. Jamie Justice, Executive Director of the $101 Million XPRIZE Healthspan. In this podcast, we discuss the world of longevity science, from the ambitious goals of this global competition to the lessons learned from the stalled TAME trial.Dr. Justice explains how the XPRIZE is structured to find real-world solutions to extend human healthspan.Chapters:
00:01:31 - Jamie's Role & The Mission of XPRIZE Healthspan00:02:29 - What is the XPRIZE Foundation?00:05:36 - The Genesis of the Healthspan Prize00:09:39 - Why Commercial Success Matters for the Prize00:10:51 - How to Win: The Competition Structure & Timeline00:18:50 - The 3 Key Healthspan Pillars: Cognitive, Physical, and Immune Function00:22:03 - Clinical Trial Design: Crossover Trials & "Responder" Analysis00:27:12 - The Types of Teams & Interventions (From Gene Therapy to Public Health)00:32:06 - Handling "Wild West" Clinics & The Importance of Data Transparency00:35:02 - How Many Teams Will Make it to the Finals?00:37:41 - Safety, Ethics, and Regulatory Hurdles00:43:42 - The FDA's Role and the Challenge of Approving "Aging" Interventions00:51:18 - The Story of the TAME Trial: Goals, Design, and Why It Stalled00:58:23 - The Real Reasons TAME Wasn't Funded (NIH Peer Review & More)01:07:09 - The Future of Large-Scale Aging Trials01:13:25 - The Good, The Bad, and The "Pheromones": Crazy XPRIZE Submissions01:16:49 - Breakdown of Finalist Categories: Drugs, Biologics, Supplements, and Multimodal Approaches01:22:20 - A Companion Prize for Biomarker Discovery01:27:30 - The Problem with "Biological Age" and Epigenetic Clocks01:31:44 - The Ethics of Using Direct-to-Consumer Age Tests in ClinicsAbout XPRIZE:XPRIZE's mission is to inspire and empower humanity to achieve breakthroughs that accelerate an equitable, abundant future.Website: Published on 4 days, 15 hours ago