Episode Details

Dr. Arun Sharma Monday 10-27-25 Space Show

Quick Summary:

Our program focused on the establishment and operations of Cedars-Sinai’s new Space Medicine Research Center, including its research programs, educational components, and institutional support. Arun discussed their stem cell research initiatives, particularly the creation of 3D heart tissue organoids grown in microgravity on the ISS, and explained their approach to training astronauts and conducting space-based medical research. The conversation covered the potential of AI and telemedicine in space missions, regulatory challenges in stem cell research, and the future opportunities presented by commercial space stations for conducting biomedical research. David and Arun were joined by participant Dr. Sherry Bell.

Detailed Summary:

David and Dr. Sherry Bell discussed the establishment of the Center for Space Medicine Research at Cedars-Sinai, led by Arun. Arun confirmed the center’s functionality and its institutional support, emphasizing its research and educational components. After Arun was welcomed back to The Space Show to discuss Cedars-Sinai Medical Center’s new Space Medicine Research Center. Arun explained that the center, established about a year ago, builds on their 10 years of work in stem cell and biomanufacturing research, including 8 missions to the ISS. He noted that the center has both research and educational components, offering courses in space medicine and biosciences as part of their master’s and PhD programs. Arun emphasized their institutional support and goal to become an academic partner for the growing private space industry in Los Angeles.

Arun discussed Cedars’ expansion beyond cardiovascular focus to broader biomanufacturing and space research, with plans to establish a clinical arm leveraging their hospital’s expertise. He mentioned ongoing conversations with local space industry players in LA, though details are not yet public. Arun also outlined their vision for a comprehensive space medicine program, including pre-flight workups, in-flight diagnostics, and post-flight checkups, while acknowledging the need for space medical training for their network of providers.

Arun further discussed his research on 3D heart tissue, or cardiac organoids, created from induced pluripotent stem cells (iPSCs). He explained that these tissues are grown in microgravity on the ISS, as microgravity may improve their growth compared to simulated microgravity on Earth. Arun clarified that the iPSCs and necessary chemicals were launched on SpaceX 33 in August and are now orbiting Earth. David inquired about astronaut training, and Arun explained that they work with engineers and partners like BioServe Space Technologies to train astronauts, as most are not life scientists. Arun expressed a desire for more direct communication with astronauts in the future.

The discussion then focused on stem cell research and space medicine training. Arun explained that stem cells are sourced from de-identified donor samples at Cedars-Sinai, with consent for medical research use. The long-term goal is to create patient-specific bioengineered organs, starting with heart tissues, though this remains an area of ongoing research. Arun clarified that the initial training program will focus on biosciences for research scientists, with plans to expand to clinical training in the future.

Arun did talk about the potential of AI and telemedicine in supporting deep space missions, emphasizing the value of human-focused research over animal studies. He clarified that his lab uses patient-specific stem cell models, focusing on human biology, and does not work with embryonic stem cells. Arun also addressed the cost and funding challenges of conducting research in space, mentioning partnerships with government agencies and the need to explore alternative funding sources for future collaboration