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Sorry, There Is No "Healthy" Drinking

Sorry, There Is No "Healthy" Drinking


Season 5 Episode 54


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For decades, the message seemed clear: a little alcohol might protect your brain. The famous U-shaped curve suggested light drinkers were safer than both heavy drinkers and non-drinkers when it came to dementia risk.

But what if this reassuring narrative was built on a fundamental misreading of the science?

In this paradigm-shifting episode, we explore a massive study using genetic data from 2.4 million people that completely dismantles the protective drinking myth. Through Mendelian randomization—a powerful technique that uses genetics to establish causation—researchers discovered the U-curve was an illusion created by reverse causation and confounding.

You'll discover:

  • Why observational studies consistently got it wrong
  • How people in early dementia often stop drinking BEFORE diagnosis, creating misleading patterns
  • What genetic analysis actually reveals: a straight-line increase in risk with any alcohol consumption
  • The staggering finding that reducing alcohol use disorder could prevent 16% of dementia cases
  • Why there appears to be no safe threshold for brain health

References:  Alcohol use and risk of dementia in diverse populations: evidence from cohort, case-control and Mendelian randomisation approaches

This is Heliox: Where Evidence Meets Empathy

Independent, moderated, timely, deep, gentle, clinical, global, and community conversations about things that matter.  Breathe Easy, we go deep and lightly surface the big ideas.

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Four recurring narratives underlie every episode: boundary dissolution, adaptive complexity, embodied knowledge, and quantum-like uncertainty. These aren’t just philosophical musings but frameworks for understanding our modern world. 

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