科研喵使用AI读文献，祝你效率百倍，访问labcat.com.cn下载。《Association of Epigenetic Age Acceleration and Mitochondrial DNA-Based Aging Metrics Provides Insights Into Mechanisms of Aging-Related Diseases》这项重要研究发表在影响因子8.0的《Aging cell》期刊上。研究发现，线粒体DNA的异常与表观遗传衰老加速密切相关：罕见异质性变异增多和线粒体DNA拷贝数减少都会加速表观遗传衰老，尤其在老年人中更为明显。更引人注目的是，表观遗传衰老指标介导了线粒体DNA拷贝数与肥胖、2型糖尿病之间的关联。这一发现为理解衰老相关疾病的机制提供了新视角，也为开发针对性干预措施奠定了基础。
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