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S2EP2 Fenbendazole’s Double Life: How a Dewormer Sparked Serious Cancer Research
Season 2 Episode 2
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We trace fenbendazole’s unlikely path from dewormer to a serious subject in oncology, clarifying how microtubules and p53 shape the scientific interest and where the evidence genuinely stands. We share practical guardrails on sourcing, clinical partnership, and mindset while separating early promise from proof.
• selective toxicity explains parasite targeting while sparing mammals
• microtubule disruption leads to mitotic arrest and apoptosis
• p53 stabilization as a potential secondary anticancer effect
• limits of preclinical data and the gap to human trials
• bioavailability, solubility and metabolism as key hurdles
• sourcing quality and COAs as non‑negotiables
• working with clinicians to monitor safety and interactions
• adopting curiosity over certainty as new data emerges
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Published on 4 weeks, 1 day ago