Episode Details

Upgrade your biology in 10 minutes with this week’s rundown from Dave Asprey. This episode breaks down the five biggest stories in biohacking and health-tech — from genetic rejuvenation to your future digital twin — giving you the tools to live longer, perform better, and stay ahead of the curve.

This episode covers:

• Vitamin D as the Surprising “Anti-Aging Pill”

A new five-year randomized study shows that daily 2,000 IU vitamin D supplementation slowed telomere shortening by 140 base pairs compared to placebo, translating to measurable gains in biological youth. Vitamin D isn’t just for bones anymore — it’s a foundational longevity molecule.

Source: Science Daily — https://www.sciencedaily.com/releases/2025/10/251022023132.htm

• The Supercentenarian Gene That Rejuvenates Old Hearts

Researchers at the University of Bristol identified a gene variant, LAV-BPIFB4, common among people living past 100, that reversed cardiac aging in animal studies — restoring blood flow, heart strength, and tissue repair with a single treatment. It’s a glimpse into how gene therapy could soon democratize superhuman longevity.

Source: University of Bristol News — https://www.bristol.ac.uk/news/2025/october/progeria.html

• FDA Closes the “GRAS” Loophole — Supplements Enter a New Era

The FDA just ended decades of self-certification for new dietary ingredients, requiring full agency review for anything entering the market. It’s the biggest shakeup in supplement regulation in years — raising quality, accountability, and trust across the entire industry.

Source: Mintz FDA Flux Newsletter — https://www.mintz.com/insights-center/viewpoints/2791/2025-10-16-fda-flux-october-2025-newsletter

• Microbes That Trigger Autophagy — Your Gut as an Anti-Aging Switch

Scientists at the University of Basel discovered that certain dietary bacteria containing double-stranded RNA can directly trigger autophagy, the body’s built-in cell-recycling system. Fermented foods like kimchi, kefir, and sauerkraut may now be proven longevity tools for activating repair from the inside out.

Source: University of Basel — https://www.unibas.ch/en/News-Events/News/Uni-Research/Longevity-research—Dietary-stress-supports-healthy-aging.html

Further reading: Neuroscience News — https://neurosciencenews.com/dietary-rna-cellular-aging-29757/

• Your Medical Avatar Is Coming — The Digital Twin of You

Forbes reports on the rise of personalized “medical avatars” — AI-powered digital twins built from your wearables and biometrics that can predict health risks, recommend interventions, and evolve alongside your biology. Doctors like Daniel Kraft call it generative health — a revolution in predictive medicine where your data literally becomes your doctor.

Source: Forbes Innovation — https://