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Episode 459: Why Insulin Matters


Episode 438


In this episode, we shine a spotlight on insulin—an often overlooked but crucial hormone that plays a central role in metabolism and overall health. While blood sugar gets a lot of attention, insulin is the key regulator behind it, influencing energy storage, fat metabolism, and cellular function. We explore how insulin resistance develops, the early signs to watch for, and why it’s so important to address this root issue to prevent chronic disease.

We also discuss how ketogenic and low-carb diets can help regulate insulin levels, improve metabolic flexibility, and support weight management. This episode provides clear, functional insights into insulin’s role and practical strategies for balancing it through nutrition and lifestyle, making it a must-listen for anyone interested in metabolic health and disease prevention.

Also in this episode: 

  • Fasting insulin <8
  • C-peptide – Reflects insulin production
  • Glucose-insulin index / HOMA-IR – Measures insulin resistance directly (calculated using fasting glucose & fasting insulin) 
  • Triglyceride:HDL ratio – Optimal <1.5 (higher = higher risk)
  • A1c – Goal <5.5% (but early IR won’t always show up here)
  • hs-CRP – Inflammation worsens insulin signaling
  • Leptin
  • Continuous Glucose Monitor
  • Conventional treatment of insulin resistance





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