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英语新闻丨世界首例!基因编辑猪肺,成功移植人体

英语新闻丨世界首例!基因编辑猪肺,成功移植人体

Episode 5 Published 6 months, 2 weeks ago
Description

A Chinese research team published a paper Monday in the British journal Nature Medicine, reporting the world's first successful transplantation of a genetically-edited pig lung into a brain-dead human recipient. 

中国科研团队于周一在英国《自然・医学》期刊发表论文,报告了全球首例基因编辑猪肺成功移植到脑死亡人体的案例。


This achievement is expected to help ease the shortage of lung donors and has been hailed by international experts as "a milestone" in the field, according to Xinhua News Agency. 


据新华社报道,这一成果有望缓解肺源短缺问题,被国际专家誉为该领域的“里程碑” 事件。


A research team led by He Jianxing, a professor at the First Affiliated Hospital of Guangzhou Medical University, transplanted a lung from a six-gene-edited pig into a 39-year-old brain-dead male human recipient following a brain hemorrhage. The lung xenograft remained viable and functional throughout the 216-hour monitoring period, without signs of hyperacute rejection or infection, according to the paper in Nature Medicine.


由广州医科大学附属第一医院何建行教授带领的科研团队,将一头经过6 处基因编辑的猪的肺脏,移植到一名因脑出血脑死亡的 39 岁男性受者体内。《自然・医学》期刊的论文显示,在 216 小时(9 天)的监测期内,这一异种移植肺始终保持存活且功能正常,未出现超急性排斥反应及感染迹象。


The donor pig had undergone six genetic edits to reduce immune risks. Postoperative monitoring of respiration, blood, and imaging showed that the transplanted lung sustained ventilation and gas-exchange functions for up to nine days, with no occurrence of hyperacute rejection during this period. Concurrent pathogen monitoring also revealed no signs of active infection, the Xinhua report said. 

报道称,供体猪共进行了6 处基因编辑,以降低免疫排斥风险。术后对呼吸、血液及影像学的监测表明,移植肺维持通气和气体交换功能达 9 天,期间未发生超急性排斥反应;同时开展的病原体监测也未发现活动性感染迹象。


As of April, more than 7.05 million people have registered as organ donors in China, the Global Times learned in April. There have been more than 58,000 organ donations, 63,000 body donations, and 110,000 corneal donations, restoring sight to 100,000, saving over 170,000 lives and supporting medical education and research. Yet, the country still faces a donor shortage.


《环球时报》4 月获悉,截至 2024 年 4 月,我国器官捐献志愿者登记人数已超 705 万。全国累计完成器官捐献超 5.8 万例、遗体捐献超 6.3 万例、角膜捐献超 11 万例,累计让 10 万名患者重见光明、17 万余名患者重获新生,并为医学教育科研提供了支持。尽管如此,我国器官供体短缺问题仍未得到根本解决。


"Currently, global demand for

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