Podcast Episode Details
Back to Podcast Episodes
Pulmonary hypertension, part 3: Early therapies and vascular physiology
Season 1 Episode 92
In this episode, we dive into the early therapies and how our understanding of vascular physiology drastically changed the management of pulmonary hypertension.
- Intro 0:12
- In this episode 0:18
- Recap of part 1 & 2 0:31
- What part 3 is about 2:31
- WHO conference in 1975: Treating pulmonary hypertension 3:48
- The Discovery of Non-Steroidal Anti-inflammatory Drugs (NSAIDs), Part 1 5:20
- Epoprostenol 6:18
- Prostacyclin 10:37
- Endothelin antagonists 11:41
- Phosphodiesterase type 5 (PDE5) inhibitors 14:08
- Interaction of nerves and blood vessels 15:06
- The Soups VS the Sparks 17:36
- A dreamed experiment 19:06
- Acetylcholine 23:23
- Enter “the calabar bean” 24:45
- Acetylcholine and vasodilation: 1976 26:01
- Rabbit aorta 27:45
- Nitric oxide 29:38
- Why are we using nitric oxide to treat pulmonary hypertension? 31:31
- Tachyphylaxis 33:48
- TNT factories 35:09
- Nitrous oxide and tachyphylaxis 36:52
- Pfizer in the 1980s 38:06
- Understanding the trigger of pulmonary hypertension 40:53
- PDE5 and nitric oxide and pulmonary hypertension 43:07
- The end of the ripping yarns 44:20
- Coming up in part 4 46:17
- Thanks for listening 47:29
We’d love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum.
References:
Bernard C. C R Soc Biol. 1851;3:163-164.
Furchgott RF, et al. Nature. 1980;doi:10.1038/288373a0.
Galiè N, et al. N Engl J Med. 2005;doi:10.1056/NEJMoa050010.
Ghofrani HA, et al. Nat Rev Drug Discov. 2006;doi:10.1038/nrd2030.
Giordano D, et al. Biochim Biophys Acta. 2001;doi:10.1016/s0167-4889(01)00086-6.
Guthrie F. Q J Chem Soc. 1859;doi:10.1039/QJ8591100245.
Higenbottam T, et al. Lancet. 1984;doi:10.1016/s0140-6736(84)91452-1.
Marsh N, et al. Clin Exp Pharmacol Physiol. 2000;doi:10.1046/j.1440-1681.2000.03240.x.
Montastruc JL, et al. Clin Auton Res. 1996;doi:10.1007/BF02281906.
Nejad SH, et al. Future Cardiol. 2024;doi:10.1080/14796678.2024.
Published on 5 months, 3 weeks ago