Episode Details

In this episode of the Peer Direct Specialist Spotlight, Gabriella Hobbs, MD and Angela Fleischman, MD, PhD discuss updates from the ASH 2024 annual meeting on emerging therapies for myelofibrosis, focusing on two agents: ilritracept and PXS-5505. Ilritracept, a modified ligand trap, showed promise in improving anemia, transfusion burden, spleen size, and symptoms, with data suggesting potential benefits in addressing ruxolitinib-associated cytopenias. PXS-5505, a pan-LOX inhibitor with antifibrotic effects, was evaluated in combination with ruxolitinib, highlighting the role of antifibrotic agents as adjunctive therapies.