Episode Details

In this episode, Dr. Morgentaler and Dr. Brandon discuss the controversial topic of testosterone therapy for men diagnosed with or treated for prostate cancer.

00:00: Introduction to Testosterone and Prostate Cancer - Dr. Morgentaler and Dr. Brandon set the stage by addressing common concerns about testosterone therapy for men with prostate cancer.

01:15: Impact of Androgen Deprivation Therapy - They discuss the effects of lowering testosterone on patients undergoing prostate cancer treatment and the long-term implications on quality of life.

03:22: Debunking Myths About Testosterone - The hosts confront the persistent fears surrounding testosterone and its perceived link to cancer recurrence.

07:40: Scientific Evidence and Case Studies - Highlighting studies and patient stories, they provide evidence that challenges outdated beliefs about testosterone therapy.

20:04: The Impact of Metastatic Disease on Life - They explore how metastatic prostate cancer affects physical and emotional well-being, emphasizing the need for balanced treatment approaches.

21:28: Understanding Biochemical Recurrence - The podcast explains the concept of biochemical recurrence, where cancer returns without visible signs, and its implications for therapy.

23:37: Testosterone Therapy After Prostate Cancer - They detail when and how testosterone therapy might be appropriate for patients post-treatment, backed by promising research data.

36:00: Concluding Thoughts and Future Directions - Wrapping up, they advocate for rethinking testosterone therapy guidelines and encourage further research to support evidence-based care.

Resources:
Watson, E., Chowdhury, S., & Williams, S. G. (2023). Testosterone therapy and prostate cancer: An update on current evidence and practice. Current Opinion in Urology, 33(6), 387–394. https://doi.org/10.1097/MOU.0000000000000989

Fralick, M., Kim, S. C., Schneeweiss, S., Glynn, R. J., Mittleman, M. A., Lee, H., & Patorno, E. (2023). Testosterone replacement therapy and risk of major adverse cardiovascular events. The New England Journal of Medicine, 388(10), 867–877. https://doi.org/10.1056/NEJMoa2215025

With Dr. Abraham Morgentaler and Dr. Marianne Brandon

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#ProstateCancer #TestosteroneTherapy #MedicalMyths