Episode Details

Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler

For a TWiV Thanksgiving, Vincent, Alan, and Kathy trace the feud over genome editing, a new virus discovered in human blood, and the origins of hepatitis A virus.

Links for this episode

• Battle over genome editing (Wired) 10:05
• First description of CRISPR in E. coli (J Bacteriol) 14:00
• Cas genes identified (Mol Micro) 14:20
• CRISPR-Cas provides immunity to bacterial viruses (Science) 15:35
• Cas9-crRNA complex mediates DNA cleavage (PNAS) 16:55
• Dual RNA-guided DNA endonuclease in bacterial immunity (Science) 17:50
• Genome engineering using CRISPR/Cas (Science) 18:50
• Cpf1 endonuclease (Cell) 23:10
• Classification of CRISPR/Cas systems (Nat Rev Micro) 23:50
• Summit on gene editing 21:25
• Novel human virus in transfusion recipients (mBio) 27:00
• Origins of hepatitis A virus in small mammals (PNAS) 55:05
• Image credit
• Letters read on TWiV 365 7:00, 1:20:35

This episode is sponsored by ASM Microbe, ASM Biodefense, and the 32nd Clinical Virology Symposium. (1:10, 1:18:30)

Weekly Science Picks 1:36:30

Kathy - Tardigrade genome sequence (video)
Alan - XKCD on Gates polio eradication site
Vincent - Lifting the Impenetrable Veil by Charles Calisher

Listener Picks

Judi - Jennifer Doudna's Ted Ta