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SONAR trial of Atrasentan
Description
Cast:
Joel Topf
Jennie Lin
Samira Farouk
Swapnil Hiremath
Show Notes:
NephJC coverage of SONAR: http://www.nephjc.com/news/sonar
SONAR in PubMed: https://www.ncbi.nlm.nih.gov/pubmed/30995972
Avosentan for overt diabetic nephropathy, the ASCEND trial: https://www.ncbi.nlm.nih.gov/pubmed/20167702
RADAR coverage at NephJC, May 2014: http://www.nephjc.com/atrasentan
RADAR in PubMed: https://www.ncbi.nlm.nih.gov/pubmed/24722445/
Google Hangout on RADAR: https://www.youtube.com/watch?v=pkkQbb-isog&feature=youtu.be
Vlado Perkovic: https://twitter.com/VladoPerkovic
SONAR: https://en.wikipedia.org/wiki/Sonar
Nephmadness adaptive trial: https://ajkdblog.org/2016/03/10/nephmadness-2016-statistics-in-nephrology-region/#adaptive
KIDNEYcon adaptive trial tweet thread: https://twitter.com/hswapnil/status/1117194018331471873?s=21
Excellent NEJM review on adaptive trials: https://www.nejm.org/doi/10.1056/NEJMra1510061
Potential role of Adaptive trials in AKI: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869991/
BNP levels in CKD: https://cjasn.asnjournals.org/content/3/6/1644
Generalizability from Wikipedia: https://en.wikipedia.org/wiki/Generalizability_theory
Anemia (and other adverse effects) of Endothelin antagonists: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210319/
Data safety monitoring boards: https://www.nidcr.nih.gov/research/human-subjects-research/interventional-studies/data-and-safety-monitoring-board-guidelines
AbbVie Allergen Merger: https://www.barrons.com/articles/abbvie-allergan-merger-pharma-deals-takeda-celgene-bristol-myers-squibb-51563890831
Tangri Kidney Failure Risk Equation: https://qxmd.com/calculate/calculator_308/kidney-failure-risk-equation-4-variable
Fragility index paper: https://www.ncbi.nlm.nih.gov/m/pubmed/24508144/
LITFL write up:
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