Episode Details

The Filtrate:

Joel Topf

Swapnil Hiremath

Samira Farouk

And special guests:

Katalin Susztak, Professor of Medicine Perlman School of Medicine, University of Pennsylvania. @KSusztak

Show Notes:

CKD-FIX: Effects of Allopurinol on the Progression of Chronic Kidney Disease

PERL: Serum Urate Lowering with Allopurinol and Kidney Function in Type 1 Diabetes

Coverage at NephJC: Effects of Allopurinol on the Progression of Chronic Kidney Disease

Richard Johnson’s theory in pay-walled Nature Reviews Nephrology: Hypothesis: fructose-induced hyperuricemia as a causal mechanism for the epidemic of the metabolic syndrome

Richard Johnson’s theory in open access Nehrology Dialysis and Transplantation: Uric acid and chronic kidney disease: which is chasing which?

PERL: Preventing early renal loss

Iohexol, good for measuring GFR as well as causing contrast associated nephropathy?

Uric acid versus urate: The Crystallization of Monosodium Urate

Association of HLA-B*5801 allele and allopurinol-induced Stevens Johnson syndrome and toxic epidermal necrolysis: a systematic review and meta-analysis

WHO list of essential medications

Fixing the numbers, specifically phosphorous

GFR Decline as an End Point for Clinical Trials in CKD: A Scientific Workshop Sponsored by the National Kidney Foundation and the US Food and Drug Administration

Cost of allopurinol: $7/month but it is only $9 for 3 months

Febuxostat Therapy for Patients With Stage 3 CKD and Asymptomatic Hyperuricemia: A Randomized Trial

Tipping point analysis - multiple imputation for stress test under missing not at random (MNAR) or a YouTube video if that’s your speed (sorry, I couldn’t find a TikTok on imputation stress tests).

Mendelian randomization study of urate and CKD by Ron Do and team

Dad jokes

Fake systematic review by Johnson’s group showing Urate lowering prevented CKD