Episode Details
Back to EpisodesBone marrow failure related to ERG insufficiency, factor 11 in vascular hyperpermeability, and new criteria for evaluating anemia in myelofibrosis
Season 8
Published 1 year, 5 months ago
Description
In this week's episode we’ll learn more about the role of ERG loss-of-function variants in bone marrow failure and hematological malignancies, a proposed pathway linking factor 11 activation to increased vascular permeability during inflammation, and new clinical criteria for diagnosing anemia, defining transfusion-dependence, and evaluating anemia treatment responses in patients with myelofibrosis.
Featured Articles:
- Germ line ERG haploinsufficiency defines a new syndrome with cytopenia and hematological malignancy predisposition
- Coagulation factor XI regulates endothelial cell permeability and barrier function in vitro and in vivo
- Proposals for revised International Working Group–European LeukemiaNet criteria for anemia response in myelofibrosis