Episode Details

Natalizumab (Tysabri, Tyruko) is approved as disease-modifying therapy (DMT) for active RRMS with a rapidly evolving severe MS.

You can read the complete article on my blog: https://ms-perspektive.com/072-natalizumab

Today we are talking about natalizumab, which is known under the trade names Tysabri and Tyruko. The immunotherapy is used for active, severe courses of relapsing forms of MS.

Natalizumab is a migration-inhibiting drug that prevents the migration of T and B cells into the central nervous system.

Please remember that I can only provide an overview here. Your neurologist and your MS nurse should give you detailed advice on choosing the right therapy for you. This is because they know your overall state of health and you should also talk about your goals, wishes, fears and preferences so that these can be taken into account.

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• General Information
• How is natalizumab (Tysabri, Tyruko) classified in immunotherapies?
• What is natalizumab (Tysabri, Tyruko) approved for?
• What is the situation for special patient groups?
• Who should avoid natalizumab?
• How does natalizumab works?
• How is it taken?
• How effective is natalizumab (Tysabri, Tyruko)?
• Risks and side effects of natalizumab (Tysabri, Tyruko)
• Vaccinations
• Sources
• Final note

Sources

I used the following sources to create the content:

• Lecture on Natalizumab by Prof. Dr. Thomas Berger as part of the Multiple Sclerosis Management Master's program
• Quality manual of the German KKNMS on natalizumab (Tysabri, Tyruko)
• MS-Selfie Infocards by Prof. Dr. Gavin Giovannoni
• German Multiple Sclerosis and Fertility Registry (DMSKW)
• Information from the German

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