Episode Details

10% of pediatric cancer is linked to a single-gene variation. These variants can be detected in embryos before pregnancy begins. Orchid’s whole genome embryo reports can help mitigate your child’s risk for cancer by screening for 90+ genetic variants linked to pediatric cancer. Discuss embryo screening and IVF with a genetics expert.

On this episode of Unsupervised Learning Razib talks about the April 2024 preprint The Genetic Origin of the Indo-Europeans. This blockbuster publication introduces nearly 300 new ancient DNA samples, uncovers the origins of the Yamnaya, and delves into how they transformed the genetic and cultural landscape of Eurasia ~5,000 years ago.

Razib addresses:

* The now-identified ancestors of the Yamnaya

* The genetic landscape between the Dnieper, Volga and Caucasus before the Yamnaya and that region’s numerous distinct populations

* When the Yamnaya came into being as a distinct genetic-cultural cluster (after 4000 BC)

* The relationship of the Yamnaya to the Anatolian Hittites and the newly refined idea of an Indo-Anatolian (as opposed to Indo-European) language family

* The region where proto-Indo-Anatolian languages likely flourished, and why they disappeared

* The population-genetic landscape of clines vs. clusters in human genetic structure over historical time