Episode Details

Join host Jimmy Nguyen as he delves into the complex interplay between antidepressants and the world of psychedelics. In this episode, special guest Dr. Ben Malcolm, the Spirit Pharmacist, unlocks the secrets of his extensive background in public health and pharmacology.

He provides a nuanced perspective on the variability in individual responses to co-administration of antidepressants and psychedelics, touching upon the complexity of conversion-related issues, absorption-related issues, and genetic variations in serotonin receptors.

The episode delves into practical approaches for individuals on different classes of antidepressants who are contemplating a psychedelic experience. Dr. Malcolm introduces the concept of "dose testing," suggesting a gradual and cautious exploration starting with microdoses to assess sensitivity. 

The conversation addresses the challenges of tapering antidepressants, emphasizing the need for a personalized and gradual approach. Dr. Malcolm offers suggestions of what to avoid during tapering and how to safely explore individual tolerance to psychedelics.

Additional Resources:

• Episode Blog Post
• The Psilocybin-Blunting Effects of SSRIs and Antidepressants
• SSRIs, Antidepressants, and Psilocybin
• Should I Stop Using Antidepressants For Psychedelic Therapy?

This podcast is edited by Chad Eschman. 

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