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EP169: What Causes Heart Attack?
Description
Welcome to my podcast. I am Doctor Warrick Bishop, and I want to help you to live as well as possible for as long as possible. I’m a practising cardiologist, best-selling author, keynote speaker, and the creator of The Healthy Heart Network. I have over 20 years as a specialist cardiologist and a private practice of over 10,000 patients.
Episode Summary
Introduction
Dr. Warrick Bishop is a practicing cardiologist and author dedicated to educating patients about heart health, believing that informed patients receive better care. In this episode, he provides a detailed explanation of how heart attacks occur, emphasizing the critical importance of understanding this process given that heart attacks account for 9 million deaths annually worldwide and affect people of all ages, including approximately 20% of victims under age 65.
Key Takeaways:
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Heart attacks result from myocardial ischemia (lack of blood flow to heart muscle) or myocardial infarction (death of heart tissue), caused by arterial blockages that prevent adequate blood supply.
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Plaque buildup in arteries begins with localized wear and tear on the arterial lining (endothelium), which triggers the body's repair process and brings cholesterol into the damaged area.
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LDL (low-density lipoprotein or "bad cholesterol") deposits cholesterol into the arterial tissue, triggering an inflammatory response where white blood cells called macrophages move in to clear excess cholesterol.
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Macrophages can become overwhelmed by excess cholesterol, swell up, and rupture, releasing destructive enzymes that cause scarring and create a foundation for calcium deposits and plaque formation.
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Fatty plaques develop a thin fibrous cap and can rupture inward into the artery, causing plaque contents to mix with blood and trigger dangerous clot formation.
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Approximately 40% or more of heart attacks occur on plaques that were not limiting blood flow prior to rupture, meaning patients can feel completely healthy right up until the artery closes off.
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The silent nature of plaque development makes cardiovascular maintenance and understanding personal risk factors critically important for prevention.
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A sudden clot blocking an artery can cause the heart muscle to become irritable and flip into a dangerous electrical rhythm that can be fatal.