Episode Details

In this episode we explore ways in which the extracellular matrix can be manipulated, including the story of doxycycline, TGF-beta in Marfan syndrome and whether beta blockers can reduce vascular events in vascular EDS.

· Intro 0:12

· Review of previous episode 0:28

· In this episode 2:26

· The pressure against the vessels 4:06

· The pressure against the wall 8:44

· Matrix metalloproteinases 10:16

· Tadpole study – collagen breakdown 10:35

· Tetracycline antibiotics 14:05

· Rat model – periodontal disease and hydroxyproline 14:24

· Chemically modified tetracyclines 20:14

· Mouse model – tetracycline use 22:00

· Tetracyclines and other autoimmune conditions 23:22

· Marfan syndrome 24:45

· Fibrillin and Marfan syndrome 28:48

· TGF-beta 29:36

· Mouse model – Marfan syndrome and fibrillin 31:14

· ARBs and TGF-beta 33:51

· TGF-beta and vascular EDS 37:25

· Back to the mouse model 38:38

· Protein kinase C 39:56

· Summary 40:26

Disclosures: Brown reports no relevant financial disclosures.

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