Episode Details

In December 2018, lifelong friends Casey MacPherson-Pomeroy and Caleb Guillory traveled to the Caribbean island of Anguilla to celebrate the holidays with their wives and another couple.

Before New Year’s Eve arrived, both men were dead.

According to accounts of the night of December 30, Casey and Caleb became violently ill after returning from a beach bar. Caleb collapsed inside the apartment and died before paramedics could save him. Casey, a medical student who reportedly attempted to help his friend, soon began suffering seizures himself and died at a hospital.

But the medical findings raised disturbing questions.

Authorities reported that both men had toxic levels of MDA and cocaine in their systems. Caleb’s death certificate also listed injuries including asphyxia, strangulation, and chest compression, while Casey’s listed seizure and serious cardiac and pulmonary complications.

Their families struggled to reconcile those findings with the men they knew.

Questions also emerged about what happened during the final hours of their lives, conflicting accounts surrounding the night, the cremation of both bodies shortly after their autopsies, and why the four surviving members of the group did not return to Anguilla to participate in a later coroner’s inquest. The surviving friends have disputed accusations against them and have said they wanted authorities to determine what caused the deaths.

Years later, no one has been charged, and the mystery surrounding the deaths of Casey MacPherson-Pomeroy and Caleb Guillory remains unresolved.

Were two lifelong friends accidentally poisoned on a Caribbean vacation? Did someone deliberately put drugs into something they consumed? And how do investigators explain the injuries documented in Caleb’s death?

This is the true crime mystery of Casey MacPherson-Pomeroy and Caleb Guillory—two friends who traveled to paradise for a celebration and never came home, leaving their families with more questions than answers.

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