Episode Details

The Filtrate:

Joel Topf

Swapnil Hiremath

Josh Waitzman

Sophia Ambruso

Priya Yenebere

With Special Guest:

Brendon Neuen, Secretariat of the SGLT2 Trialists Consortium and cool guy on Twitter.

Editor:

Sophia Ambruso

Show Notes:

Joel’s Conflict of Interest Statement. Sophia is also conflicted with Astra Zeneca and Brendon with everybody in the SGLT2i space.

Joel starts off with a history of SGLT2i

EMPA-REG Outcomes. First!

CANVAS. OMG this signal is reproducible!

CREDENCE (🎧). It works in a dedicated population at high risk of kidney disease. And in a study designed for renal end-points.

DAPA-CKD (🎧). It’s not just for diabetics!

EMPA-Kidney. It works at really low GFR. And without albuminuria. And again in non-diabetics.

SGLT Inhibitors for Type 1 Diabetes: Proceed With Extreme Caution

Click to find the supplement (requires a subscription)

Differences in definition in the decreased renal function component of the composite primary outcomes.

EMPA-Kidney 40%

DAPA-Kidney 50%

CREDENCE doubling of serum Cr

Usability Testing of a Sick-Day Protocol in CKD (Pubmed)

New Guidelines for Statistical Reporting in the Journal (link, commentary on said guidelines by Frank Harrell)

CKD outcomes and the FDA: Change in Albuminuria and GFR as End Points for Clinical Trials in Early Stages of CKD: A Scientific Workshop Sponsored by the National Kidney Foundation in Collaboration With the US Food and Drug Administration and European Medicines Agency

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