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This Fortnight in Medicine XII
Effects of Intensive Blood Pressure Control in Patients With Frailty: A Post Hoc Analysis From ESPRIT
* Lowering systolic blood pressure to less than 120 mm Hg versus less than 140 mm Hg in patients w…
Published on 8 hours ago
This Fortnight in Medicine XI
Total cholesterol and all-cause mortality by sex and age: a prospective cohort study among 12.8 million adults
* The Ideal Cholesterol Level ... Depends...And Cannot Be Determined From Observational S…
Published on 2 weeks ago
This Fortnight in Medicine X
Two papers this week, with a bunch of articles that we referenced in the conversation. Also, the last Fortnight podcast was accidentally posted behind a paywall. It is now up and free to listen to. M…
Published on 4 weeks ago
This Fortnight in Medicine IX
We go all observational this week. A look at data suggesting the safety of GLP-1s and a re-examination of data on patient/doctor race concordance/discordance (a topic Adam said we should not study, a…
Published on 1 month, 1 week ago
Friday Reflection 53: Eradicating the Very Important Patient from the Medical Ecosystem
NT is a 55-year-old man admitted to the general medicine service with cellulitis of his left leg. When the attending sees him the morning after admission, he notices the patient’s “Medical Center Tru…
Published on 1 month, 2 weeks ago
Friday Reflection 52: The Three Worst Phone Calls of My Career
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Published on 1 month, 3 weeks ago
This Fortnight in Medicine VIII
Last week, John was at the European Society of Cardiology conference in Madrid, and Adam was at the Preventing Overdiagnosis 2025 International Conference in Oxford. A conversation about what we lear…
Published on 1 month, 3 weeks ago
This Fortnight in Medicine VII
Metformin for Treatment of Knee Osteoarthritis in Patients With Overweight or Obesity
Once-Weekly Semaglutide in Persons with Obesity and Knee Osteoarthritis
Semaglutide or Tirzepatide and Optic Nerve …
Published on 2 months, 1 week ago
Friday Reflection 50: The Look
TR is a 72-year-old woman, a retired executive, who had been in excellent health until she began experiencing exertional dyspnea and palpitations. After waiting out the symptoms for about a month, sh…
Published on 2 months, 3 weeks ago
This Fortnight in Medicine VI
A “manel” reviewing trials and studies that explore the benefits and harms of hormone replacement therapy.
The Women’s Health Initiative
* Risks and benefits of estrogen plus progestin in healthy postm…
Published on 2 months, 3 weeks ago