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Drug-resistant epilepsy: Dr. Patrick Kwan



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About one-third of people with epilepsy will continue having seizures despite medications. What is the clinical definition of drug-resistant epilepsy? Why does it occur, and…


Published on 7 hours ago

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Normalizing depression in epilepsy: Screening, diagnosis, treatment - Dr. Rosa Michaelis



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Nearly 1 in 4 people with epilepsy experiences depression, which affects quality of life, seizure control, and adherence to treatment. Depressive symptoms - including suicid…


Published on 2 weeks ago

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A novel patient-reported outcome measure for epilepsy: The impacts of seizures and treatment



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Is there a fast, simple way to measure whether someone with epilepsy is doing "better" or "worse" compared with a past clinic visit? Not really. Seizure count is often consi…


Published on 4 weeks ago

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Social work in epilepsy: Closing the treatment gap and improving quality of life - Dr. Rugare Mugumbate



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Closing the epilepsy treatment gap relies heavily on social and cultural acceptance of epilepsy as a brain disorder that can be managed with medication or other therapies. D…


Published on 1 month, 1 week ago

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Somatic genetic epilepsies: Dr. Christian Bosselmann



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Somatic genetic epilepsies arise from mutations that occur early in fetal development. They are usually only detectable by genetic sequencing of tissue. For these epilepsies…


Published on 1 month, 3 weeks ago

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Research recap: Empiric immunotherapy for highly refractory epilepsy: Dr. Elisabeth Doran



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In a retrospective study of 31 patients with highly refractory epilepsy, 29% had more than a 50% reduction in seizures for at least 12 months after being treated with immuno…


Published on 2 months, 2 weeks ago

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Genetic testing: Variants of uncertain significance (VUS) - Dr. Gemma Carvill



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What are variants of uncertain significance (VUS) in epilepsy genetic testing? How are they defined, and can those definitions change over time? Sharp Waves talks with Dr. G…


Published on 3 months ago

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What's new in status epilepticus: Dr. Eugen Trinka



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This episode covers a wide scope of issues, including treatment options, treatment response, prognosis and the role of seizures versus the underlying etiology, most common e…


Published on 3 months, 2 weeks ago

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Valproate and reproductive risks in women and men with epilepsy: Dr. Tony Marson



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In use since the 1970s, valproate is highly effective for genetic generalized epilepsies and some forms of pediatric epilepsy. The medication also is associated with a 10% r…


Published on 4 months ago

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ILAE Updated seizure classification: Dr. Sandor Beniczky



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ILAE's updated seizure classification position paper was published in Epilepsia in April 2025. Sharp Waves talked with Dr. Sandor Beniczky about the updates and how they wil…


Published on 4 months, 2 weeks ago





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